{"id":1214,"date":"2023-03-20T09:16:56","date_gmt":"2023-03-20T01:16:56","guid":{"rendered":"https:\/\/app.lemaidi888.com\/?p=1214"},"modified":"2023-03-20T09:16:56","modified_gmt":"2023-03-20T01:16:56","slug":"%e6%9d%a5%e9%82%a3%e6%9b%bf%e5%b0%bc-698387-09-6-%e7%91%9e%e5%a8%81%e5%b0%94%e7%94%9f%e7%89%a9%e7%a7%91%e6%8a%80","status":"publish","type":"post","link":"https:\/\/app.lemaidi888.com\/?p=1214","title":{"rendered":"\u6765\u90a3\u66ff\u5c3c | 698387-09-6 | \u745e\u5a01\u5c14\u751f\u7269\u79d1\u6280"},"content":{"rendered":"\n
\u4e2d\u6587\u540d<\/td>\u6765\u90a3\u66ff\u5c3c<\/td><\/tr>
\u4e2d\u6587\u540c\u4e49<\/td>\u6765\u90a3\u66ff\u5c3c\u3001HKI-272;\u6765\u90a3\u66ff\u5c3c, \u4e00\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u7684HER2\u548cEGFR\u6291\u5236\u5242;\u8bfa\u62c9\u66ff\u5c3c;\u6765\u90a3\u66ff\u5c3c NERATINIB;\u6765\u90a3\u66ff\u5c3c-\u4e2d\u95f4\u4f533;\u6765\u90a3\u66ff\u5c3c\u6742\u8d28E;\u6765\u90a3\u66ff\u5c3c\u6742\u8d28(A-D);\u6765\u90a3\u66ff\u5c3c,(2E)-N-[4-[[3-\u6c2f-4-[(\u5421\u5576-2-\u57fa)\u7532\u6c27\u57fa]\u82ef\u57fa]\u6c28\u57fa]-3-\u6c30\u57fa-7-\u4e59\u6c27\u57fa\u55b9\u5549-6-\u57fa]-4-(\u4e8c\u7532\u57fa\u6c28\u57fa)\u4e01-2-\u70ef\u9170\u80fa<\/td><\/tr>
\u82f1\u6587\u540d<\/td>Neratinib<\/td><\/tr>
\u82f1\u6587\u540c\u4e49<\/td>(2e)-n-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide;Neratinib(HKI-272);(2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide;neratinib;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide;Unii-jjh94R3pwb;HKI-272; HKI272; HKI 272<\/td><\/tr>
CAS<\/td>698387-09-6<\/strong><\/td><\/tr>
\u5206\u5b50\u5f0f<\/td>C30H29ClN6O3<\/td><\/tr>
\u5206\u5b50\u91cf<\/td>557.04<\/td><\/tr>
EINECS<\/td>811-237-1<\/td><\/tr>
\u7ed3\u6784\u5f0f<\/td>\"\u6765\u90a3\u66ff\u5c3c\"<\/td><\/tr>
\u6027\u8d28<\/td><\/tr>
\u6cb8\u70b9<\/td>757.0\u00b160.0 \u00b0C(Predicted)<\/td><\/tr>
\u5bc6\u5ea6<\/td>1.33<\/td><\/tr>
\u5f62\u6001<\/td>Off-white solid.<\/td><\/tr>
\u9178\u5ea6\u7cfb\u6570(pKa)<\/td>12.37\u00b10.43(Predicted)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u672c\u516c\u53f8\u7684\u6240\u6709\u4ea7\u54c1\u4ec5\u7528\u4e8e\u79d1\u5b66\u7814\u7a76\u6216\u8005\u5de5\u4e1a\u5e94\u7528\u7b49\u975e\u533b\u7597\u76ee\u7684\uff0c\u4e0d\u53ef\u7528\u4e8e\u4eba\u7c7b\u6216\u52a8\u7269\u7684\u4e34\u5e8a\u8bca\u65ad\u6216\u6cbb\u7597\uff0c\u975e\u836f\u7528\uff0c\u975e\u98df\u7528\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e2d\u6587\u540d \u6765\u90a3\u66ff\u5c3c \u4e2d\u6587\u540c\u4e49 \u6765\u90a3\u66ff\u5c3c\u3001HKI-272;\u6765\u90a3\u66ff\u5c3c, \u4e00\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u7684HER2\u548cEGFR\u6291\u5236\u5242;\u8bfa […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1214","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/1214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1214"}],"version-history":[{"count":1,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/1214\/revisions"}],"predecessor-version":[{"id":1215,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/1214\/revisions\/1215"}],"wp:attachment":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}