{"id":924,"date":"2023-02-07T10:52:49","date_gmt":"2023-02-07T02:52:49","guid":{"rendered":"https:\/\/app.lemaidi888.com\/?p=924"},"modified":"2023-02-07T10:52:50","modified_gmt":"2023-02-07T02:52:50","slug":"%e7%94%b2%e6%b0%a8%e8%9d%b6%e5%91%a4-59-05-2-%e7%91%9e%e5%a8%81%e5%b0%94%e7%94%9f%e7%89%a9%e7%a7%91%e6%8a%80","status":"publish","type":"post","link":"https:\/\/app.lemaidi888.com\/?p=924","title":{"rendered":"\u7532\u6c28\u8776\u5464 | 59-05-2 | \u745e\u5a01\u5c14\u751f\u7269\u79d1\u6280"},"content":{"rendered":"\n
\u4e2d\u6587\u540d<\/td>\u7532\u6c28\u8776\u5464<\/td><\/tr>
\u4e2d\u6587\u540c\u4e49<\/td>METHOTREXATE \u7532\u6c28\u8776\u5464;\u80fa\u7532\u558b\u5464\u6c34\u5408\u7269;\u7532\u6c28\u8776\u5464\u3001\u7532\u6c28\u8776\u5464\u6c34\u5408\u7269;\u7532\u6c28\u8776\u5464 \u56db\u5ddd\u5382\u5bb6;\u6c28\u7532\u8776\u5464\/\u7532\u6c28\u8776\u5464\/\u7532\u6c28\u57fa\u53f6\u9178\/\u6c28\u7532\u53f6\u9178\/\u5bf9-[(2,4-\u4e8c\u6c28\u57fa\u558b\u5576-6)-N-\u7532\u57fa\u7532\u6c28\u57fa]\u82ef\u7532\u9170\u8c37\u6c28\u9178\/\u4e8c\u6c34\u5408\u6c28\u7532\u560c\u5464\/(+)\u6c28\u7532\u8776\u5464\/N-[4-[[(2,4-\u4e8c\u6c28\u57fa-6-\u8776\u5576)\u7532\u57fa]\u7532\u6c28\u57fa]\u82ef\u7532\u9170]-L-\u8c37\u6c28\u9178;CAS:59-05-2\u6216133073-73-1;\u7532\u6c28\u8776\u5464,\u4e8c\u6c34\u5408 5G;\u7532\u6c28\u8776\u5464\u539f\u6599\u836f<\/td><\/tr>
\u82f1\u6587\u540d<\/td>Methotrexate<\/td><\/tr>
\u82f1\u6587\u540c\u4e49<\/td>METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe<\/td><\/tr>
CAS<\/td>59-05-2<\/strong><\/td><\/tr>
\u5206\u5b50\u5f0f<\/td>C20H22N8O5<\/td><\/tr>
\u5206\u5b50\u91cf<\/td>454.44<\/td><\/tr>
EINECS<\/td>200-413-8<\/td><\/tr>
\u7ed3\u6784\u5f0f<\/td>\"\u7532\u6c28\u8776\u5464\"<\/td><\/tr>
\u6027\u8d28<\/td><\/tr>
\u7194\u70b9<\/td>195\u00b0C<\/td><\/tr>
\u6bd4\u65cb\u5149\u5ea6<\/td>+17\uff5e+24\u00b0(D\/20\u2103)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)<\/td><\/tr>
\u6cb8\u70b9<\/td>561.26\u00b0C (rough estimate)<\/td><\/tr>
\u5bc6\u5ea6<\/td>1.4080 (rough estimate)<\/td><\/tr>
\u6298\u5c04\u7387<\/td>1.6910 (estimate)<\/td><\/tr>
\u95ea\u70b9<\/td>11\u2103<\/td><\/tr>
\u50a8\u5b58\u6761\u4ef6<\/td>\u221220\u00b0C<\/td><\/tr>
\u6eb6\u89e3\u5ea6<\/td>H2<\/sub>O: insoluble<\/td><\/tr>
\u5f62\u6001<\/td>powder<\/td><\/tr>
\u9178\u5ea6\u7cfb\u6570(pKa)<\/td>pKa 3.04\/4.99(H2O,t =25,I=0.0025) (Uncertain)<\/td><\/tr>
\u6c34\u6eb6\u89e3\u6027<\/td>Insoluble. <0.1 g\/100 mL at 19 \u00baC<\/td><\/tr>
\u654f\u611f\u6027<\/td>Light Sensitive & Hygroscopic<\/td><\/tr>
Merck<\/td>14,5985<\/td><\/tr>
BRN<\/td>70669<\/td><\/tr>
\u7a33\u5b9a\u6027<\/td>Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.<\/td><\/tr>
InChIKey<\/td>FBOZXECLQNJBKD-ZDUSSCGKSA-N<\/td><\/tr>
(IARC)\u81f4\u764c\u7269\u5206\u7c7b<\/td>3 (Vol. 26, Sup 7) 1987<\/td><\/tr>
NIST\u5316\u5b66\u7269\u8d28\u4fe1\u606f<\/td>Methotrexate(59-05-2)<\/td><\/tr>
EPA\u5316\u5b66\u7269\u8d28\u4fe1\u606f<\/td>Methotrexate (59-05-2)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u672c\u516c\u53f8\u7684\u6240\u6709\u4ea7\u54c1\u4ec5\u7528\u4e8e\u79d1\u5b66\u7814\u7a76\u6216\u8005\u5de5\u4e1a\u5e94\u7528\u7b49\u975e\u533b\u7597\u76ee\u7684\uff0c\u4e0d\u53ef\u7528\u4e8e\u4eba\u7c7b\u6216\u52a8\u7269\u7684\u4e34\u5e8a\u8bca\u65ad\u6216\u6cbb\u7597\uff0c\u975e\u836f\u7528\uff0c\u975e\u98df\u7528\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u4e2d\u6587\u540d \u7532\u6c28\u8776\u5464 \u4e2d\u6587\u540c\u4e49 METHOTREXATE \u7532\u6c28\u8776\u5464;\u80fa\u7532\u558b\u5464\u6c34\u5408\u7269;\u7532\u6c28\u8776\u5464\u3001\u7532\u6c28\u8776\u5464\u6c34\u5408\u7269;\u7532\u6c28 […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-924","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=924"}],"version-history":[{"count":1,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/924\/revisions"}],"predecessor-version":[{"id":925,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=\/wp\/v2\/posts\/924\/revisions\/925"}],"wp:attachment":[{"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/app.lemaidi888.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}