中文名甲氨蝶呤

中文同义METHOTREXATE 甲氨蝶呤;胺甲喋呤水合物;甲氨蝶呤、甲氨蝶呤水合物;甲氨蝶呤 四川厂家;氨甲蝶呤/甲氨蝶呤/甲氨基叶酸/氨甲叶酸/对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸/二水合氨甲嘌呤/(+)氨甲蝶呤/N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸;CAS:59-05-2或133073-73-1;甲氨蝶呤,二水合 5G;甲氨蝶呤原料药

英文名Methotrexate

英文同义METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS59-05-2

分子式C20H22N8O5

分子量454.44

EINECS200-413-8

结构式

性质

熔点195°C

比旋光度+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)

沸点561.26°C (rough estimate)

密度1.4080 (rough estimate)

折射率1.6910 (estimate)

闪点11℃

储存条件−20°C

溶解度H2O: insoluble

形态powder

酸度系数(pKa)pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

水溶解性Insoluble. <0.1 g/100 mL at 19 ºC

敏感性Light Sensitive & Hygroscopic

Merck14,5985

BRN70669

稳定性Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.

InChIKeyFBOZXECLQNJBKD-ZDUSSCGKSA-N

(IARC)致癌物分类3 (Vol. 26, Sup 7) 1987

NIST化学物质信息Methotrexate(59-05-2)

EPA化学物质信息Methotrexate (59-05-2)

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